Background: Nipple adenoma is a very uncommon, benign proliferative process of lactiferous ducts of the nipple.\nClinically, it often presents as a palpable nipple nodule, a visible nipple skin erosive lesion, and/or with discharge\nfrom the surface of the nipple skin, and is primarily seen in middle-aged women. Resultantly, nipple adenoma can\nclinically mimic the presentation of mammary Paget�s disease of the nipple. The purpose of our current case report\nis to present a comprehensive review of the available data on nipple adenoma, as well as provide useful information to\nhealth care providers (including dermatologists, breast health specialists, and other health care providers) who evaluate\npatients with dermatologic conditions of the breast skin for appropriately clinically recognizing, diagnosing, and\ntreating patients with nipple adenoma.\nCase presentation: Fifty-three year old Caucasian female presented with a one year history of erythema and\ninduration of the skin of the inferior aspect of the right nipple/areolar region. Skin punch biopsies showed\nsubareolar duct papillomatosis. The patient elected to undergo complete surgical excision with right central\nbreast resection. Final histopathologic evaluation confirmed nipple adenoma. The patient is doing well\n31 months after her definitive surgical therapy.\nConclusions: Since nipple adenoma represents a benign proliferative process of the nipple, complete surgical\nexcision is curative. However, the coexistence of nipple adenoma and ipsilateral or contralateral breast cancer is\nwell reported in the literature. The potential for a direct causal link or association of nipple adenoma and breast\ncancer cannot be fully excluded.
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